| # | Chief Minister | From | To | Tenure |
|---|---|---|---|---|
| 1 | Muhammad Ayub Khoro | Fri, Aug 15, 1947 | Mon, Apr 26, 1948 | 0 Y 8 M 11 D |
| 2 | Pir Elahi Bux | Mon, May 03, 1948 | Fri, Feb 04, 1949 | 0 Y 9 M 1 D |
| 3 | Yousif Haroon | Fri, Feb 18, 1949 | Sun, May 07, 1950 | 1 Y 2 M 19 D |
| 4 | Qazi Fazalullah | Mon, May 08, 1950 | Thu, May 24, 1951 | 1 Y 0 M 16 D |
| 5 | Muhamamd Ayub Khoro | Fri, Mar 23, 1951 | Sat, Dec 29, 1951 | 0 Y 9 M 6 D |
| 6 | Pirzada Abdul Star | Fri, May 22, 1953 | Mon, Nov 08, 1954 | 1 Y 5 M 17 D |
| 7 | Muhammad Ayub Khoro | Mon, Nov 08, 1954 | Tue, Dec 13, 1955 | 1 Y 1 M 5 D |
| 8 | Mumtaz Ali Bhutto | Mon, May 01, 1972 | Thu, Dec 20, 1973 | 1 Y 7 M 19 D |
| 9 | Ghulam Mustafa Jatoi | Sat, Dec 22, 1973 | Tue, Jul 05, 1977 | 3 Y 6 M 13 D |
| 10 | Ghous Ali Shah | Sat, Apr 06, 1985 | Wed, Apr 06, 1988 | 3 Y 0 M 0 D |
| 11 | Akhtar Ali Qazi | Sun, Apr 10, 1988 | Sun, May 29, 1988 | 0 Y 1 M 19 D |
| 12 | Akhtar Ali Qazi (Caretaker) | Sat, Aug 13, 1988 | Fri, Dec 02, 1988 | 0 Y 3 M 19 D |
| 13 | Syed Qaim Ali Shah | Fri, Dec 02, 1988 | Sat, Feb 24, 1990 | 1 Y 2 M 22 D |
| 14 | Aftab Shahban Mirani | Sat, Feb 24, 1990 | Mon, Aug 06, 1990 | 0 Y 5 M 13 D |
| 15 | Jam Sadiq Ali | Mon, Aug 06, 1990 | Thu, Mar 05, 1992 | 1 Y 6 M 28 D |
| 16 | Syed Muzaffar Hussain Shah | Fri, Mar 06, 1992 | Fri, Jul 09, 1993 | 1 Y 4 M 3 D |
| 17 | Syed Ali Madad Shah (Caretaker) | Mon, Jul 19, 1993 | Tue, Oct 19, 1993 | 0 Y 3 M 0 D |
| 18 | Syed Abdullah Shah | Wed, Oct 20, 1993 | Wed, Nov 06, 1996 | 3 Y 0 M 17 D |
| 19 | Mumtaz Ali Bhutto (Caretaker) | Thu, Nov 07, 1996 | Sat, Feb 22, 1997 | 0 Y 3 M 15 D |
| 20 | Liaqat Ali Jatoi | Sat, Feb 22, 1997 | Fri, Oct 30, 1998 | 1 Y 8 M 8 D |
| 21 | Ali Muhammad Khan Mahar | Sat, Jun 08, 2002 | Sun, Jun 06, 2004 | 1 Y 11 M 29 D |
| 22 | Arbab Ghulam Rahim | Tue, Jun 08, 2004 | Mon, Nov 19, 2007 | 3 Y 5 M 11 D |
| 23 | Abdul Qadir Halipota (Caretaker) | Tue, Nov 20, 2007 | Sun, Apr 06, 2008 | 0 Y 4 M 17 D |
| 24 | Syed Qaim Ali Shah | Sun, Apr 06, 2008 | Wed, Mar 20, 2013 | 4 Y 11 M 14 D |
| 25 | Zahid Qurban Alvi (Caretaker) | Wed, Mar 21, 2012 | Thu, May 30, 2013 | 1 Y 2 M 9 D |
| 26 | Syed Qaim Ali Shah | Thu, May 30, 2013 | Fri, Jul 29, 2016 | 3 Y 1 M 29 D |
| 27 | Syed Murad Ali Shah | Fri, Jul 29, 2016 | Thu, May 31, 2018 | 1 Y 10 M 2 D |
| 28 | Fazal ur Rehman (Caretaker) | Sat, Jun 02, 2018 | Wed, Aug 15, 2018 | 0 Y 2 M 13 D |
| 29 | Syed Murad Ali Shah | Thu, Aug 16, 2018 | Wed, Feb 15, 2023 | 4 Y 5 M 30 D |
| 30 | Maqbool Baqar | Tue, Aug 15, 2023 | Tue, Feb 27, 2024 | 0 Y 6 M 12 D |
| 31 | Syed Murad Ali Shah | Tue, Feb 27, 2024 | Present |
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